Roger D Cone Selected Research

Melanocortins

1/2022	Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.
1/2021	Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome.
1/2019	Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.
1/2017	Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.
4/2013	Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
6/2012	Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.
6/2011	Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
3/2011	Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.
12/2007	Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling.
7/2007	Creation of a genetic model of obesity in a teleost.

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Roger D Cone Research Topics

Disease

25	Obesity 01/2022 - 07/2002
9	Hyperphagia (Overeating) 01/2021 - 06/2003
8	Body Weight (Weight, Body) 01/2018 - 05/2003
7	Cachexia 06/2011 - 04/2003
5	Weight Loss (Weight Reduction) 01/2021 - 04/2003
5	Anorexia 01/2021 - 07/2002
4	Hypertension (High Blood Pressure) 01/2017 - 04/2003
4	AIDS-Related Complex (ARC) 07/2006 - 06/2003
4	Weight Gain 06/2005 - 07/2003
3	Hypertrophy 01/2021 - 03/2006
2	Insulin Resistance 03/2016 - 12/2007
2	Inflammation (Inflammations) 06/2012 - 12/2007
2	Uremia 09/2006 - 06/2005
2	Malnutrition (Nutritional Deficiencies) 09/2006 - 03/2005
1	Glucose Intolerance 01/2019
1	Anorexia Nervosa 01/2019
1	Mental Disorders (Mental Disorder) 01/2019
1	Blindness (Hysterical Blindness) 11/2018
1	Retinal Degeneration 01/2018
1	Epilepsy (Aura) 01/2018
1	Renal Insufficiency (Renal Failure) 01/2018
1	Diabetes Mellitus 01/2018
1	Cardiac Arrhythmias (Arrythmia) 01/2018
1	Bradycardia 01/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017
1	Hyperplasia 03/2016
1	Infertility (Sterility) 03/2016
1	Morbid Obesity 06/2012
1	Fatty Liver 12/2007
1	Chronic Kidney Failure (Chronic Renal Failure) 09/2006
1	Chronic Renal Insufficiency 03/2005
1	Thinness 04/2004
1	Neoplasms (Cancer) 04/2003
1	Fever (Fevers) 04/2003

Drug/Important Bio-Agent (IBA)

19	MelanocortinsIBA 01/2022 - 07/2002
17	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 01/2021 - 04/2003
10	LeptinIBA 01/2022 - 11/2003
9	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2021 - 04/2003
6	Peptides (Polypeptides)IBA 01/2019 - 06/2003
5	Type 3 Melanocortin ReceptorIBA 01/2021 - 04/2003
4	CytokinesIBA 09/2006 - 04/2003
3	Agouti-Related ProteinIBA 01/2021 - 01/2004
2	AdipokinesIBA 01/2022 - 09/2006
2	Pharmaceutical PreparationsIBA 01/2020 - 06/2003
2	LipidsIBA 01/2019 - 03/2011
2	setmelanotideIBA 10/2017 - 04/2015
2	SaltsIBA 06/2012 - 04/2003
2	gamma-MSHIBA 11/2006 - 04/2003
2	alpha-MSHIBA 11/2006 - 04/2003
2	GhrelinIBA 09/2006 - 07/2006
2	Blood Proteins (Serum Proteins)IBA 09/2006 - 03/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2006 - 03/2005
2	Hormones (Hormone)IBA 09/2006 - 07/2006
2	CorticosteroneIBA 11/2003 - 04/2003
2	Melanocortin Receptors (Melanocortin Receptor)IBA 06/2003 - 04/2003
1	tubastatin AIBA 01/2022
1	Histone Deacetylase 6IBA 01/2022
1	ArrestinIBA 10/2019
1	Ion Channels (Ion Channel)IBA 01/2019
1	PotassiumIBA 01/2019
1	GTP-Binding Proteins (G-Protein)IBA 01/2019
1	Retinaldehyde (Retinal)IBA 11/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	ElectrolytesIBA 01/2018
1	Biological ProductsIBA 01/2018
1	Leptin ReceptorsIBA 03/2016
1	CarbohydratesIBA 04/2013
1	AutoreceptorsIBA 06/2011
1	N-acylphosphatidylethanolamineIBA 03/2011
1	Dietary Fats (Dietary Fat)IBA 03/2011
1	ResistinIBA 09/2006
1	AdiponectinIBA 09/2006
1	Interleukin-1 (Interleukin 1)IBA 09/2006
1	Interleukin-6 (Interleukin 6)IBA 09/2006
1	Cocaine (Cocaine HCl)IBA 07/2006
1	Amphetamine (Amfetamine)FDA LinkGeneric 07/2006
1	4-Nle-7-Phe-alpha- MSHIBA 03/2006
1	Ubiquitin CIBA 06/2005
1	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2005
1	NeuropeptidesIBA 03/2005
1	InterleukinsIBA 03/2005
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2004
1	CeruleninIBA 01/2004
1	Pheromones (Semiochemicals)IBA 11/2003
1	Hydrocortisone (Cortisol)FDA LinkGeneric 11/2003
1	Testosterone (Sustanon)FDA Link 11/2003
1	Insulin (Novolin)FDA Link 11/2003
1	trkB ReceptorIBA 07/2003
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 07/2003
1	FenfluramineIBA 06/2003
1	5-HT2C Serotonin ReceptorIBA 06/2003
1	Serotonin (5 Hydroxytryptamine)IBA 06/2003
1	Appetite Depressants (Anorectics)IBA 06/2003
1	Neuropeptide YIBA 06/2003
1	LipopolysaccharidesIBA 04/2003

Therapy/Procedure

2	Therapeutics 01/2021 - 06/2012
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 06/2012
1	Injections 11/2006
1	Fat-Restricted Diet (Diet, Fat Restricted) 06/2003